14.14 Red cell folate (categories 3)
Over detection limit <14900 vs ≥14900.
14.14.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 314.979852 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 2.701767 | 1 | 0.1 | ns |
| GA_samp | 91.008623 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 33.967504 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 2.501515 | 1 | 0.1 | ns |
| GA_samp | 1678.317810 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 566.365724 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 4.710131 | 1 | 0.03 | * |
| GA_samp | 779.739710 | 1 | <0.0001 | *** |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 1.930 | 1.930 | 0.2 | ns |
| GA_samp | 1 | Inf | 2.869 | 2.869 | 0.09 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 1.630 | 1.630 | 0.2 | ns |
| GA_samp | 1 | Inf | 2.215 | 2.215 | 0.1 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 2.315 | 2.315 | 0.1 | ns |
| GA_samp | 1 | Inf | 1.029 | 1.029 | 0.3 | ns |
14.14.2 Model summary
Ratio of Geometric means (95% CI)
| Var | Effect | P |
|---|---|---|
| (Intercept) | 18.05 (13.12, 24.83) | <0.0001 |
| rcfolate_gp3≥14900 | 1.07 (0.99, 1.16) | 0.10 |
| GA_samp | 1.13 (1.10, 1.16) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.70 (1.42, 2.03) | <0.0001 |
| rcfolate_gp3≥14900 | 0.96 (0.92, 1.01) | 0.11 |
| GA_samp | 1.36 (1.34, 1.39) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.06 (0.05, 0.07) | <0.0001 |
| rcfolate_gp3≥14900 | 0.93 (0.88, 0.99) | 0.03 |
| GA_samp | 1.33 (1.30, 1.36) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 8.07 (5.51, 11.81) | <0.0001 |
| rcfolate_gp3≥14900 | 1.08 (0.97, 1.20) | 0.16 |
| GA_samp | 1.03 (1.00, 1.06) | 0.09 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.74 (1.17, 2.61) | 0.007 |
| rcfolate_gp3≥14900 | 1.08 (0.96, 1.20) | 0.20 |
| GA_samp | 1.03 (0.99, 1.06) | 0.14 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 4.87 (4.56, 5.21) | <0.0001 |
| rcfolate_gp3≥14900 | 1.02 (0.99, 1.04) | 0.13 |
| GA_samp | 1.00 (0.99, 1.00) | 0.31 |
14.14.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
14.14.4 Estimated marginal means
| Outcome | rcfolate_gp3 | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| PRL (ng/ml) | <14900 | 73.126 | 5.474 | 69.360 | 62.983 | 84.903 |
| PRL (ng/ml) | ≥14900 | 78.147 | 5.839 | 68.978 | 67.326 | 90.709 |
| hPL (μg/ml) | <14900 | 59.412 | 1.867 | 67.936 | 55.800 | 63.258 |
| hPL (μg/ml) | ≥14900 | 57.204 | 1.797 | 67.858 | 53.728 | 60.904 |
| GH2 (ng/ml) | <14900 | 1.495 | 0.051 | 100.542 | 1.397 | 1.600 |
| GH2 (ng/ml) | ≥14900 | 1.396 | 0.048 | 100.355 | 1.304 | 1.493 |
| Insulin (uU/ml) | <14900 | 11.221 | 0.408 | Inf | 10.449 | 12.050 |
| Insulin (uU/ml) | ≥14900 | 12.091 | 0.474 | Inf | 11.196 | 13.057 |
| HOMA-IR | <14900 | 2.371 | 0.092 | Inf | 2.198 | 2.558 |
| HOMA-IR | ≥14900 | 2.549 | 0.105 | Inf | 2.351 | 2.764 |
| Glucose (mmol/L) | <14900 | 4.717 | 0.037 | Inf | 4.646 | 4.789 |
| Glucose (mmol/L) | ≥14900 | 4.802 | 0.043 | Inf | 4.720 | 4.886 |
14.14.6 Post-hoc comparisons
| Outcome | Contrast | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|
| PRL (ng/ml) | ≥14900 / <14900 | 1.07 (0.99, 1.16) | 0.1 |
| hPL (μg/ml) | ≥14900 / <14900 | 0.96 (0.92, 1.01) | 0.1 |
| GH2 (ng/ml) | ≥14900 / <14900 | 0.93 (0.88, 0.99) | 0.03 |
| Insulin (uU/ml) | ≥14900 / <14900 | 1.08 (0.97, 1.20) | 0.2 |
| HOMA-IR | ≥14900 / <14900 | 1.08 (0.96, 1.20) | 0.2 |
| Glucose (mmol/L) | ≥14900 / <14900 | 1.02 (0.99, 1.04) | 0.1 |